Pharmaceutical Packaging and Filling Machinery

Reliable Gas Flow and Dew Point Measurement for Process Gases in Filling and Packaging Machines

In aseptic filling and packaging processes, stable values for humidity, temperature, air velocity and differential pressure are essential for product safety, sterility and shelf life. Packaging machines operate in controlled environments where even minor fluctuations in air quality or pressure can lead to contamination or sealing defects. At the same time, connected process gas lines—such as compressed air, nitrogen, oxygen or argon must be continuously monitored to ensure dryness, efficiency and compliance with GMP and FDA/21 CFR requirements. Moisture in compressed air can cause corrosion, quality issues and machine downtime; leaks significantly increase operating costs. E+E Elektronik provides sensor systems combining robust protection mechanisms, traceable accuracy and digital connectivity to ensure stable, compliant and energy-efficient operation along aseptic filling lines.

  • Protective coatings, catalytic filters and intelligent sensor-protection technologies ensure resistance against sterilisation and aggressive cleaning agents (e.g. H2O2)
  • Auto-zero differential pressure monitoring prevents drift and ensures long-term stability
  • High-accuracy, long-term stable gas-flow and dew-point sensors enable continuous process-gas monitoring even at very low flow rates and low dew points
  • Sensors calibrated with traceability according to DIN EN ISO/IEC 17025 support documentation requirements under GMP and FDA/21 CFR
  • Modular, digital integration enables fast commissioning and seamless system connectivity

Advantages of Pharmaceutical Packaging and Filling Machinery with E+E Sensors

Even minor pressure deviations can compromise containment in sterile zones or increase energy use. E+E’s differential pressure sensors, such as EE610 and EE600, include an auto-zero calibration feature that periodically compensates for offset drift from long-term operation, temperature changes and filter loading. This ensures stable readings and consistent control of cleanroom pressure cascades, leakage detection systems and airflow balance—helping maintain both sterility and efficiency with minimal manual intervention.

Packaging and filling lines frequently undergo hydrogen peroxide (H₂O₂) vapour decontamination and alcohol-based cleaning to maintain aseptic conditions. These procedures place severe chemical and thermal stress on sensitive measurement elements. E+E sensors are engineered for such environments, featuring protective coatings, catalytic filters, and the proven AutoReCovery function (ARC) that helps restore sensor performance after solvent or disinfectant exposure. Together, these technologies ensure long-term measurement stability, minimise drift from repeated sterilisation cycles, improve reliability, and reduce the need for frequent calibration.

E+E Elektronik offers a comprehensive measurement portfolio that covers humidity, temperature, differential pressure, air velocity, air flow and dew point. Sensors feature a uniform interface design, consistent accuracy, and shared calibration principles and documentation. This unified approach simplifies mechanical and electrical integration, shortens validation time, and reduces supplier complexity.

Measurement integrity is vital for validation and compliance in aseptic packaging systems. In addition to the standard ISO factory calibration, E+E sensors can be calibrated in the company’s EN ISO/IEC 17025-accredited, in-house laboratory, traceable to national metrology institutes (NMI). This ensures high measurement accuracy with complete, traceable documentation for GMP and FDA audits. Whether monitoring differential pressure to maintain pressure cascades and cleanroom separation, or humidity to prevent moisture-sensitive product defects, E+E’s accredited calibration provides confidence in every reading while reducing requalification effort and audit risk.

Large packaging machines often consume significant amounts of conditioned air. Unstable airflow or unnoticed leaks increase energy demand and risk contamination. Integrated digital interfaces, such as IO-Link or Modbus RTU, together with easy bus configuration, ensure simple connectivity and allow continuous data collection for energy monitoring and process optimisation. These innovations ensure consistent process control, quick calibration checks, and straightforward integration into existing control architectures..

Products for Pharmaceutical Packaging and Filling Machinery

EE680

Air Velocity and Temperature Sensor for Laminar Flow

  • 0 to 2 m/s (0 to 400 ft/min)
  • -20 to +70 °C (-4 to +158 °F)
  • analog outputs (0–5 V / 0–10 V / 0–20 mA / 4–20 mA)
  • Modbus RTU
  • resistance against H₂O₂
  • LED ring for status indication
HTS801 humidity and temperature sensor

HTS801

Humidity and Temperature Sensor for High Humidity and Chemically Polluted Conditions

  • -80 °C to 180 °C (-112 °F to 356 °F)
  • 300 bar (4 350 psi)
  • RS485 (Modbus RTU)
  • E+E proprietary coating
  • IP65 / NEMA 4
  • polycarbonate or stainless-steel enclosure
  • several probe and cable lengths available
  • for chemical contamination
  • for continuous high humidity conditions
HTP501 - Digital Humidity and Temperature Probe

HTP501

Digital Humidity and Temperature Probe up to 120 °C (248 °F)

  • 0–100 % RH
  • −40 to +120 °C (−40 to +248 °F)
  • E+E proprietary coating
  • stainless-steel enclosure
  • Modbus RTU
  • M12 connector
Sigma 05 - Modular Sensor Platform

Sigma 05

Modular Sensor Platform

  • up to 3 sensing probes
  • up to 5 measurands
  • polycarbonate or metal enclosure
  • IP65 / NEMA 4X
EE741 - flow meter for compressed air and gases

EE741

Inline Flow Sensor for Compressed Air and Gases

  • O₂, N₂, Ar or CO₂ in DN15 to DN50 pipes
  • 7 bar (102 psi)
  • Modbus RTU / M-Bus / IO-Link
  • E+E hot film sensing element
  • Robust design in stainless steel
Dew point transmitter EE355

EE355

Dew Point Sensor down to -60 °C Td (-76 °F Td)

  • down to −60 °C Td (−76 °F)
  • -40 to 70°C (-40 to +158°F)
  • up to 80 bar (1,160 psi)
  • RS485 (Modbus RTU)
  • stainless-steel housing
  • IP65 protection
EE160 humidity temperature sensor

EE160

Humidity and Temperature Sensor for Building Automation

Questions about Pharmaceutical Packaging and Filling Machinery?

Tell us about your application – we’ll recommend a suitable sensor or calibration solution tailored to your needs.

Matthew Nemeth | Managing Director E+E Elektronik Corporation USA
Matthew Nemeth | Managing Director E+E Elektronik Corporation USA
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