Pharmaceutical Plants

Reliable Monitoring in Controlled Pharmaceutical Environments

In pharmaceutical production facilities, accurate and stable measurement is essential for product integrity, patient safety and regulatory compliance. Cleanrooms, laboratories and controlled storage areas must meet strict GMP and ISO 14644 requirements, where even small deviations in temperature, humidity, differential pressure or air velocity can impact quality. Continuous environmental monitoring, accredited calibration and data integrity according to GAMP 5 and FDA 21 CFR Part 11 are key to maintaining compliant and efficient operation. E+E Elektronik provides cleanroom-ready sensor solutions offering long-term stability, EN ISO/IEC 17025-traceable accuracy and seamless BMS/EMS integration. Robust designs, protective coatings and dedicated filter caps support resistance to alcohol-based cleaning and periodic H₂O₂ decontamination, ensuring reliable measurements and simplified validation.

  • Long-term stability for continuous GMP and ISO 14644 environmental monitoring
  • Traceable accuracy via in-house, accredited calibration according to EN ISO/IEC 17025
  • Cleanroom-compatible designs with options for resistance to alcohols and periodic H₂O₂ decontamination
  • Seamless BMS/EMS integration via analog and digital interfaces (0–10 V, 4–20 mA, Modbus RTU, BACnet MS/TP)
  • Reduced maintenance and validation effort through consistent performance

Advantages of E+E Sensors in Pharmaceutical Plants

With more than 40 years of experience and high vertical integration — from the sensing element to the calibrated device — E+E Elektronik delivers measurement reliability, compliance-ready monitoring, and long-term data stability for pharmaceutical plants worldwide. E+E sensors and software are built for the accuracy and traceability needs of cleanroom and controlled-environment applications, with accredited calibration available for humidity, dew point, CO₂, air velocity/flow, temperature, and pressure. Calibrations are performed in E+E’s EN ISO/IEC 17025-accredited laboratory (Akkreditierung Austria, ID 0608). The portfolio supports environmental monitoring in GMP Grade A/B (ISO Class 5) through ISO Class 8 areas — for example, the EE680 laminar-flow probe is specified for GMP Grade A/B and ISO 5 and above — while optional SmartGraph/HUMLOG software variants address FDA 21 CFR 11 requirements for electronic records

E+E cleanroom sensors — for example the GMP-compliant EE680 laminar-flow probe and the EE610 differential pressure sensor — are engineered for long-term stability in GMP-grade areas. Protective E+E sensor coatings, stainless-steel enclosures/connectors, and PTFE catalytic H₂O₂ filter caps help maintain accuracy even after repeated cleaning and H₂O₂ decontamination. This robustness helps minimise measurement drift during sterilisation and supports dependable performance in continuous operation.

 

From cleanroom airlocks and HVAC ducts to sterile production zones and storage areas, E+E offers a unified sensor portfolio for humidity, temperature, differential pressure, and air velocity/flow. With the modular Sigma 05 platform and dedicated cleanroom devices such as EE610 (low differential pressure) and EE680 (laminar-flow air velocity), the portfolio supports consistent measurement performance across all plant areas — from a single, trusted supplier.

Devices are typically supplied with a factory calibration certificate (EN 10204-3.1/2.2). On request, accredited ISO/IEC 17025 calibration certificates document traceability to SI and national standards; for selected measurands E+E acts as a BEV Designated Institute (NMI level). Periodic verification is easily performed with the Omniport 40 portable reference device, enabling fast on-site checks and — where applicable — direct probe adjustment.  Digital calibration certificates provide immediate availability and simplify documentation. Together, these measures support ongoing GMP qualification and validation and help reduce the effort for requalification.

E+E transmitters integrate seamlessly into central monitoring systems for building management (BMS) and environmental monitoring (EMS). Analog outputs (4–20 mA, 0–10 V) and digital interfaces such as RS485 with Modbus RTU or BACnet MS/TP — and on selected models Ethernet PoE with Modbus TCP — enable reliable communication with common BMS/EMS platforms. The sensors’ stability and harmonised design help streamline qualification, validation, and long-term environmental data logging.

Products for Pharmaceutical Plants

AVS701 – Highly accurate air and gas velocity sensor for industrial applications | E+E Elektronik

AVS701

Highly Accurate Air and Gas Velocity Sensor for Industrial Applications

  • -40 to +140 °C (-40 °F to 284°F)
  • 0 to 40 m/s (0 to 8 000ft/min)
  • IP65 / NEMA 4X
  • for demanding industrial applications
  • high-end ceramic sensing element
  • stainless steel sensor head and probe
  • Modbus RTU
High-End Humidity and Temperature  Sensor for Industrial Applications

EE310

High-End Humidity and Temperature Sensor for Industrial Applications

  • 0–100 % RH
  • −40 to +180 °C (−40 to +356 °F)
  • 0.01–20 bar (0.15 to 290 psi)
  • RS485 (Modbus RTU)
  • accuracy ±0.95% RH
  • for clean rooms
  • for pharmaceutical industry
  • industrial process monitoring

EE07

Temperature Probe with Digital Interface

  • 0–100 % RH
  • −40 to +80 °C (−40 to +176 °F)
  • ±0.1 °C accuracy (±1.18 °F)
  • polycarbonate or stainless-steel housing
  • IP65 protection
HTP501 - Digital Humidity and Temperature Probe

HTP501

Digital Humidity and Temperature Probe up to 120 °C (248 °F)

  • 0–100 % RH
  • −40 to +120 °C (−40 to +248 °F)
  • E+E proprietary coating
  • stainless-steel enclosure
  • Modbus RTU
  • M12 connector
EE300Ex Humidity transmitter for intrinsically safe applications

EE300Ex

Humidity and Temperature Sensor for Intrinsically Safe Applications

  • -40 to +180 °C (-40 to +356 °F)
  • 2-wire 4–20 mA
  • intrinsically safe (ATEX / IECEx / FM / NEPSI / KCs)
  • E+E proprietary coating
  • Pressure tight up to 20 bar (300 psi)
  • IP65 / NEMA 4
  • for explosive gas and dust atmospheres
  • Stainless steel enclosure and probe
HTS801 humidity and temperature sensor

HTS801

Humidity and Temperature Sensor for High Humidity and Chemically Polluted Conditions

  • -80 °C to 180 °C (-112 °F to 356 °F)
  • 300 bar (4 350 psi)
  • RS485 (Modbus RTU)
  • E+E proprietary coating
  • IP65 / NEMA 4
  • polycarbonate or stainless-steel enclosure
  • several probe and cable lengths available
  • for chemical contamination
  • for continuous high humidity conditions

EE610

Low Differential Pressure Sensor

  • 0...25 / 50 / 75 / 100 Pa
  • –20…60 °C (–4…140 °F)
  • Accuracy: ±0.5 Pa = ±0.5 % FS
  • Auto-zero function
  • Analogue output: 0–10 V or 4–20 mA
  • Modbus RTU (RS485)
  • IP65 / NEMA 4X housing

EE600

Differential Pressure Sensor

  • 0…250 / 500 / 750 / 1 000 Pa
  • 0…2 500 / 5 000 / 7 500 / 10 000 Pa
  • ±250 / ±500 / ±750 / ±1 000 Pa
  • ±2 500 / ±5 000 / ±7 500 / ±10 000 Pa
  • –20…60 °C (–4…140 °F)
  • Accuracy: ±0.5 % FS
  • Auto-zero function
  • Analogue output: 0–10 V or 4–20 mA
  • Modbus RTU (RS485)

EE680

Air Velocity and Temperature Sensor for Laminar Flow

  • 0 to 2 m/s (0 to 400 ft/min)
  • -20 to +70 °C (-4 to +158 °F)
  • analog outputs (0–5 V / 0–10 V / 0–20 mA / 4–20 mA)
  • Modbus RTU
  • resistance against H₂O₂
  • LED ring for status indication

EE660

Low Air Velocity Sensor

  • 0 to 2 m/s
  • RS485 (Modbus RTU)
  • hot-film anemometer thin-film sensor element
  • low-velocity measurement from 0.15 m/s (30 ft/min)
  • IP65 / NEMA 4X
EE354 Dew point meter

EE354

Dew Point Sensor down to -20 °C Td (-4 °F Td)

  • dew point down to –20 °C Td (–4 °F Td)
  • –20 to +50 °C Td (–4 to +122 °F Td)
  • RS485 (Modbus RTU)
  • up to 80 bar (1,160 psi)
  • stainless-steel housing
  • IP65 / NEMA 4X
EE850 CO₂ and Temperature Sensor for Duct Mounting

EE850

CO₂ and Temperature Sensor for Duct Mounting

  • 0–2 000 / 10 000 ppm CO₂
  • −20 to +60 °C (−4 to +140 °F)
  • analogue outputs (0–10 V / 4–20 mA)
  • Modbus RTU
  • IP 65/ NEMA 4X
  • Probe: OP20
CO₂ sensor EE820

EE820

CO₂ Sensor for Demanding Applications

  • 0–100 % RH
  • –20…60 °C (–4…140 °F)
  • CO₂: 0–2 000 / 5 000 / 10 000 ppm
  • CO₂ accuracy: ±50 ppm ±2 %
  • Analogue output: 0–10 V or 4–20 mA
  • IP54 protection rating

Questions about Pharmaceutical Plants?

Tell us about your application – we’ll recommend a suitable sensor or calibration solution tailored to your needs.

Matthew Nemeth | Managing Director E+E Elektronik Corporation USA
Matthew Nemeth | Managing Director E+E Elektronik Corporation USA
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